Sarcoidosis is a rare multisystem chronic granulomatous, with unknown etiology. Neurological involvement in sarcoidosis is rare and occurs in 5 to 15% of cases. 1 LIMBIC structures involvement in sarcoidosis is unusual and uncommon. Herein, we report a case of LIMBIC ENCEPHALITIS (LE) as the first manifestation of neurosarcoidosis. . . .

Introduction LIMBIC ENCEPHALITIS, a relatively newly described condition, usually courses with an insidious onset of episodic memory loss, confusion, and agitation (1). The role of immune dysregulation in its pathophysiology has been extensively investigated. A recent study reported the prevalence and incidence rates of AUTOIMMUNE ENCEPHALITIS (AE) as 13. 7/100, 000 and 0. 8/100, 000 person-years which was not significantly different compared to infectious ENCEPHALITIS (2). Herein, we summarize different aspects of AE...

Paraneoplastic neurological syndromes have only been described with pleural mesothelioma in five cases. We have described a 72-year-old man who developed anterograde amnesia 27 months after diagnosis of epithelioid pleural mesothelioma.Investigations revealed a LIMBIC ENCEPHALITIS with no alternative causes identified. LIMBIC ENCEPHALITIS is a classical paraneoplastic syndrome and presentation within five years of a cancer with no other causes identified is sufficient to diagnose a paraneoplastic etiology. This is the first case of isolated paraneoplastic LIMBIC ENCEPHALITIS driven by a pleural mesothelioma.

Background: AUTOIMMUNE ENCEPHALITIS (AIE) with neural cell autoantibodies is a treatable category of non-viral ENCEPHALITIS in children and adolescents which presents with neuropsychiatric manifestations. Anti-N-methyl-D-aspartate receptor ENCEPHALITIS, the most common identified type of AIE, is more frequent than individual viral ENCEPHALITIS in young patients. Early diagnosis and treatment of the disease have been associated with improvement in the majority of patients. Case Report: we report two pediatric cases with acute neuropsychiatric presentations in whom the diagnosis of AIE was proved based on the cerebrospinal fluid (CSF) antineuronal antibodies in one and on clinical and paraclinical grounds in another seronegative patient. Immunotherapy in both patients resulted in improvement. No underlying tumor was found in patients. Pediatricians should be aware of manifestations, investigations, and treatment of AIE and consider it as the differential diagnosis of ENCEPHALITIS.

Simple herpetic and non-herpetic LIMBIC en-cephalitis (NHLE) are known causes of LIMBIC ENCEPHALITIS. The age of onset of NHLE is higher among young women (1). Moreover, NHLE is associated with the development of malformative teratomas in the abdominal cavity. The clinical course is varied with symptoms such as hallucina-tions, visual delusions, and dementia-like symp-toms (1). . . .